•Aim 1: Characterize contributions of common genetic variation to lung cancer etiology.
•Aim 2: Investigate role of rare variants in lung cancer susceptibility.
•Aim 3: Identify genetic effects on smoking behavior
•Aim 4: Characterize joint effects of environmental and genetic interactions on lung cancer risk
Deliverables Year 1:
- Need to complete analyses by ethnic subpopulation and consider comparative and random effects models.
- Selected Initial analyses of rare variants are completed along with some methodology approaches by Hung and McKay groups.
- Smoking behavior GWAS impact being studied for lung cancer risk by Chen and Bierut, effects of smoking on carcinogenesis being pursued by LeMarchand.
- Preliminary Interaction analyses completed by Li et al, but extremely conservative approach was used and should be repeated.
- Supplement to study BRCA2 may be funded (hopeful, but could resubmit).
- Need to complete NLST revision.
- Need to integrate additional GWAS from GELCC and Asian studies.